Current projects

Current student projects

Current Topics for Bachelor and Master Projects in Ecotoxicology

Direct in vivo measurements of accumulation and efflux activity of pharmaceuticals and environmental xenobiotics in single embryos of the gastropod great pond snail (Lymnaea stagnalis)

Supervisors: Knud, Henrik

 

  • Combination effects of pharmaceuticals
  • Effects of chemicals
  • Activity and inhibition of efflux pumps
  • Chemosensitization

Mercury in the environment

Supervisors: Poul

 

  • Mercury in sediments
  • Baselines of mercury in un-contaminated food chains
  • Selenium-mercury interactions

Reproductive endocrinology of mollusks and development of biomarkers for endocrine disrupters

Supervisors: Knud, Jane, Henrik, Poul

 

  • Development of ELISA for quantification of yolk protein in the blue mussel (Mytilus edulis)
  • Induction of intersex in bivalves
  • Basic endocrinology of bivalves

Ex vivo spiggin mRNA measurements as a biomarker of androgenic and anti-androgenic activity of xenobiotics

Supervisors: Knud in collaboration with Steffen Madsen

 

  • Dose-response ex vivo investigation of androgenic effects on spiggin mRNA in sticklebacks (Gasterosteus aculeatus) and immunohistology

Effects of pharmaceuticals (selective serotonin reuptake inhibitors, SSRIs) on embryo activity and development in the great pond snail (Lymnaea stagnalis)

Supervisors: Knud, Henrik

 

  • Effects of dopamine and serotonin on embryo rotation
  • Effects of SSRIs on embryo development

Endocrine disruption in fish

Supervisors: Poul, Jane, Henrik

 

  • Effects of thyroid disruption in zebrafish
  • Studies on potential biomarkers for thyroid disruption

Examples of former Bachelor and Master Projects

Former Bachelor Projects

 

Practical projects

  • Ex vivo investigations of androgen influence on spiggin mRNA in stickleback (Gasterosteus aculeatus)
  • Biological mercury-selenium interactions in the shore crab (Carcinus maenas)
  • Investigation of intersex peppery furrow shell (Scrobicularia plana) by histology
  • Annual variation in yolk protein levels in the swollen river mussel (Unio tumidus) - important background knowledge for the development of a biomarker.

 

Literature studies

  • Obesogenes – are they a reason for obesity?
  • The humoral specific immune system in teleost fish
  • Copper regulation in crustaceans
  • The role of sex steroid hormones in molluscs
  • Food-drug interactions
  • Teratogenic effects of pharmaceuticals
  • Endocrine disrupting effects of parabens
  • The Testicular Dysgenesis Syndrome
  • The influence of human genetic polymorphismon the side effects of anti-psychotic pharmaceuticals
  • Metabolic syndrome: a possible link to exposure for endocrine disrupting compounds and certain pharmaceuticals
  • Effects of weak painkillers on embryo development in humans

 

 

Former Master Projects

 

  • The effect of dopamine and serotonin on rotational behavior in embryos of great pondsnail Lymnaea stagnalis
  • Effects of serotonin on molluscs. Method development and investigations of the effects of serotonin and escitalopram on Lymnaea stagnalis embryo development and behavior.
  • Development of an ELISA for quantification of egg yolk protein in the freshwater mussel Unio pictorum and Unio tumidus. Investigations the influence of food availability on protein concentrations.
  • Interactions between mercury and selenium in aquatic organisms
  • Endocrine effects in the population of brown trout in Danish streams
  • Trenbolone in the environment and effects on rainbow trout pituitary
  • Expression and function of ictacalcin in brown trout (Salmo trutta)
  • Measurements of cellular accumulation and pump efficiency for determinations of inhibitory effects of pharmaceuticals on efflux pumps in eggs from Lymnaea stagnalis
  • Combination effects of quinidine and verapamil on efflux pumps in Lymnaea stagnalis
  • Effects of obesogenic chemicals on efflux pumps in embryos of Lymnaea stagnalis.
  • Development of computer models, estimating binding affinities, for prediction of in vitro
  • activation of the PPAR gamma nuclear receptor by xenobiotics
  • The influence of weak painkillers on prostaglandin synthesis and sexual differentiation in zebrafish (Danio rerio)
  • Effects of endocrine disrupting chemicals on embryo development in eelpout (Zoarces viviparus)
  • Development of OECD guideline for the testing of chemicals
  • Intersex in the marine snail Littorina littorea related to areas with TBT exposure
  • Effect of selenium on the elimination of methylmercury in crustaceans
  • The estrogenic effects of cyclo siloxanes in zebrafish
  • The estrogenic effect of biochanin A in brown trout

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